Relapsing typhilitis to CFHR5 nephropathy: the thrill of discovery
نویسندگان
چکیده
منابع مشابه
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Complement is an important aspect of defence against infection and its activation and regulation are finely balanced. Disordered complement regulation can lead to C3 glomerulonephritis (C3GN), which is characterized by complement (but not immunoglobulin) deposition in the glomerulus of the kidney. Although only recently recognized as a clinical entity, C3GN is important and elucidation of its m...
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Complement factor H related protein 5 (CFHR5) nephropathy is a monogenic disorder of complement regulation that is endemic in Cyprus. The disease is characterised by haematuria, C3 glomerulonephritis and kidney failure. Its identification suggests a role for the CFHR5 protein in the regulation of complement in the kidney. In this review, we discuss how studying CFHR5 nephropathy can contribute ...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 2011
ISSN: 0141-0768,1758-1095
DOI: 10.1258/jrsm.2011.11k018